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Article

The planar polarity gene strabismus regulates convergent extension movements in Xenopus.

The EMBO journal - 1 Mar 2002

Darken Rachel S, Scola Adriane M, Rakeman Andrew S, Das Gishnu, Mlodzik Marek, Wilson Paul A

Abstract excerpt

The signaling mechanisms that specify, guide and coordinate cell behavior during embryonic morphogenesis are poorly understood. We report that a Xenopus homolog of the Drosophila planar cell polarity gene strabismus (stbm) participates in the regulation of convergent extension, a critical morphogenetic process required for the elongation of dorsal structures in vertebrate embryos. Overexpression of Xstbm, which...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Animals
Cell Movement
Cloning, Molecular
Cytoskeletal Proteins
DNA, Complementary
Dishevelled Proteins
Drosophila Proteins
Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Embryo, Nonmammalian

Gastrula

Gene Expression Regulation, Developmental

Larva

Membrane Proteins

Mesoderm

Molecular Sequence Data

Morphogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 11867525
DOI: 10.1093/emboj/21.5.976
PMCID: PMC125882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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