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Article

An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.

The Journal of biological chemistry - 29 Jun 2001

Ono K, Ohtomo T, Sato S, Sugamata Y, Suzuki M, Hisamoto N, Ninomiya-Tsuji J, Tsuchiya M, Matsumoto K

Abstract excerpt

TAK1, a member of the MAPKKK family, is involved in the intracellular signaling pathways mediated by transforming growth factor beta, interleukin 1, and Wnt. TAK1 kinase activity is specifically activated by the TAK1-binding protein TAB1. The C-terminal 68-amino acid sequence of TAB1 (TAB1-C68) is sufficient for TAK1 interaction and activation. Analysis of various truncated versions of TAB1-C68 defined a...

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Source

Identifiers

PMID: 11323434
DOI: 10.1074/jbc.M102631200

Genes

TAB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.PMID 11323434Read ↗

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A mouse model for functional dissection of TAB1 O-GlcNAcylationSemantic proximity Read ↗

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Semantic proximity Read ↗

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.Semantic proximity Read ↗

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules.Semantic proximity Read ↗

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.Semantic proximity Read ↗

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.Semantic proximity Read ↗

A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation.Semantic proximity Read ↗

TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling.Semantic proximity Read ↗

The N-terminal domain of TIR domain-containing adaptor molecule-1, TICAM-1.Semantic proximity Read ↗

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