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Article

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules.

JCI insight - 23 Aug 2018

De Nicola Gian F, Bassi Rekha, Nichols Charlie, Fernandez-Caggiano Mariana, Golforoush Pelin Arabacilar, Thapa Dibesh, Anderson Rhys, Martin Eva Denise, Verma Sharwari, Kleinjung Jens, Laing Adam, Hutchinson Jonathan P, Eaton Philip, Clark James, Marber Michael S

Abstract excerpt

Inhibiting MAPK14 (p38α) diminishes cardiac damage in myocardial ischemia. During myocardial ischemia, p38α interacts with TAB1, a scaffold protein, which promotes p38α autoactivation; active p38α (pp38α) then transphosphorylates TAB1. Previously, we solved the X-ray structure of the p38α-TAB1 (residues 384-412) complex. Here, we further characterize the interaction by solving the structure of the pp38α-TAB1...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 30135318
DOI: 10.1172/jci.insight.121144
PMCID: PMC6141180

Genes

TAB1
MAPK14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules.PMID 30135318Read ↗

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