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Article

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.

Genes & development - 15 Nov 2005

Shim Jae-Hyuck, Xiao Changchun, Paschal Amber E, Bailey Shannon T, Rao Ping, Hayden Matthew S, Lee Ki-Young, Bussey Crystal, Steckel Michael, Tanaka Nobuyuki, Yamada Gen, Akira Shizuo, Matsumoto Kunihiro, Ghosh Sankar

Abstract excerpt

TGF-beta-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-kappaB and AP-1 and, therefore, plays a crucial role in regulating the genes that mediate inflammation. Although in vitro biochemical studies have revealed the existence of a TAK1 complex, which includes TAK1 and the adapter proteins TAB1 and TAB2, it remains unclear which...

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Source

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Identifiers

PMID: 16260493
DOI: 10.1101/gad.1360605
PMCID: PMC1283960

Genes

TAB1
TAB2
TNF
IRAK1
TLR3
TLR4
TRAF2
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.PMID 16260493Read ↗

Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.Semantic proximity Read ↗

Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.Semantic proximity Read ↗

TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.Semantic proximity Read ↗

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.Semantic proximity Read ↗

TGF-beta-activated kinase 1 and TAK1-binding protein 1 cooperate to mediate TGF-beta1-induced MKK3-p38 MAPK activation and stimulation of type I collagen.Semantic proximity Read ↗

Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.Semantic proximity Read ↗

Generation of a conditional mutant allele for Tab1 in mouse.Semantic proximity Read ↗

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.Semantic proximity Read ↗

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.Semantic proximity Read ↗

TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation.Semantic proximity Read ↗

TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB.Semantic proximity Read ↗

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.Semantic proximity Read ↗

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