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Article

TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling.

The Journal of biological chemistry - 30 Apr 2010

Li Meng, Wang He, Huang Tao, Wang Jiyong, Ding Yu, Li Zhenfei, Zhang Jinkuo, Li Lin

Abstract excerpt

The TAK1-NLK cascade is a mitogen-activated protein kinase-related pathway that plays an inhibitory role in canonical Wnt/beta-catenin signaling through regulating the LEF1/TCF family transcriptional factors. TAB2 (TAK1-binding protein 2) is a putative TAK1 interacting protein that is involved in the regulation of TAK1. Here, we found that TAB2 could directly interact with NLK and function as a scaffold protein...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20194509
DOI: 10.1074/jbc.M109.083246
PMCID: PMC2859499

Genes

TAB2
NLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling.PMID 20194509Read ↗

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Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.Semantic proximity Read ↗

Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.Semantic proximity Read ↗

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Semantic proximity Read ↗

An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.Semantic proximity Read ↗

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.Semantic proximity Read ↗

The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.Semantic proximity Read ↗

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