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Article

A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation.

The Journal of biological chemistry - 25 Jun 2010

Tatematsu Megumi, Ishii Akihiro, Oshiumi Hiroyuki, Horiuchi Masataka, Inagaki Fuyuhiko, Seya Tsukasa, Matsumoto Misako

Abstract excerpt

The Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 (TICAM-1, also called TRIF) is a signaling adaptor for TLR3 and TLR4 that activates the transcription factors IRF-3, NF-kappaB, and AP-1, leading to induction of type I interferon and cytokines. The N-terminal region of TICAM-1 participates in IRF-3 activation, although the C-terminal region is involved in NF-kappaB activation. However, the...

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Source

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Identifiers

PMID: 20418377
DOI: 10.1074/jbc.M109.099101
PMCID: PMC2888425

Genes

TBK1
TLR3
TLR4
TRAF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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