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Article

Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.

PloS one - 1 Jan 2011

Wolf Alexander, Beuerlein Knut, Eckart Christoph, Weiser Hendrik, Dickkopf Beate, Müller Helmut, Sakurai Hiroaki, Kracht Michael

Abstract excerpt

TAB1 was defined as a regulatory subunit of the protein kinase TAK1, which functions upstream in the pathways activated by interleukin (IL)-1, tumor necrosis factor (TNF), toll-like receptors (TLRs) and stressors. However, TAB1 also functions in the p38 MAPK pathway downstream of TAK1. We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22216226
DOI: 10.1371/journal.pone.0029256
PMCID: PMC3245275

Genes

TAB1
CCL5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.PMID 22216226Read ↗

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