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Article

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.

Science (New York, N.Y.) - 15 Feb 2002

Ge Baoxue, Gram Hermann, Di Padova Franco, Huang Betty, New Liguo, Ulevitch Richard J, Luo Ying, Han Jiahuai

Abstract excerpt

Phosphorylation of mitogen-activated protein kinases (MAPKs) on specific tyrosine and threonine sites by MAP kinase kinases (MAPKKs) is thought to be the sole activation mechanism. Here, we report an unexpected activation mechanism for p38alpha MAPK that does not involve the prototypic kinase cascade. Rather it depends on interaction of p38alpha with TAB1 [transforming growth factor-beta-activated protein kinase...

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Source

Identifiers

PMID: 11847341
DOI: 10.1126/science.1067289

Genes

TAB1
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.PMID 11847341Read ↗

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