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Article

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.

Mechanisms of development - 1 Dec 2002

Komatsu Yoshihiro, Shibuya Hiroshi, Takeda Naoki, Ninomiya-Tsuji Jun, Yasui Teruhito, Miyado Kenji, Sekimoto Tomohisa, Ueno Naoto, Matsumoto Kunihiro, Yamada Gen

Abstract excerpt

The transforming growth factor-beta (TGF-beta) superfamily consists of a group of secreted signaling molecules that perform important roles in the regulation of cell growth and differentiation. TGF-beta activated kinase-1 binding protein-1 (TAB1) was identified as a molecule that activates TGF-be...

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Source

Identifiers

PMID: 12464436
DOI: 10.1016/s0925-4773(02)00391-x

Genes

TAB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12464436-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.PMID 12464436Read ↗

Generation of a conditional mutant allele for Tab1 in mouse.Semantic proximity Read ↗

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migrationSemantic proximity Read ↗

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Semantic proximity Read ↗

The TGF beta activated kinase TAK1 regulates vascular development in vivo.Semantic proximity Read ↗

Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis.Semantic proximity Read ↗

A mouse model for functional dissection of TAB1 O-GlcNAcylationSemantic proximity Read ↗

TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development.Semantic proximity Read ↗

TGF-beta-activated kinase 1 and TAK1-binding protein 1 cooperate to mediate TGF-beta1-induced MKK3-p38 MAPK activation and stimulation of type I collagen.Semantic proximity Read ↗

Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.Semantic proximity Read ↗

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.Semantic proximity Read ↗

Haploinsufficiency of TAB2 causes congenital heart defects in humans.Semantic proximity Read ↗

An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.Semantic proximity Read ↗

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