Article
Protein accumulation and gene mutation of p53 in bilateral breast cancer. South-East Sweden Breast Cancer Group.
Acta oncologica (Stockholm, Sweden) - 1 Jan 2001
Stenmark-Askmalm M, Gentile M, Wingren S, Ståhl O
Abstract excerpt
The aim of this study was to investigate the frequency of p53 alterations in bilateral breast cancer and to evaluate a possible clonal relationship between the paired tumours regarding p53 alteration and other pathobiological variables. Tumours from 34 patients were investigated with immunohistochemistry, single strand conformation polymorphism analysis and DNA-sequence analysis applied to exons 5-8. Fifteen...
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