Article
Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers.
Journal of the National Cancer Institute - 3 Jun 1992
Thor A D, Moore DH I I, Edgerton S M, Kawasaki E S, Reihsaus E, Lynch H T, Marcus J N, Schwartz L, Chen L C, Mayall B H
Abstract excerpt
BACKGROUND: Mutations of the tumor suppressor gene p53 have been identified in breast cancer cell lines, and some breast carcinomas are detectable by immunohistochemical assay because of p53 protein accumulation. PURPOSE: This study was designed to determine whether p53 protein accumulation in br...
Topics
- Age Factors
- Biomarkers, Tumor
- Breast Neoplasms
- Carcinoma, Intraductal, Noninfiltrating
- Cell Line
- Codon
- Female
- Genes, p53
- Humans
- Lymphatic Metastasis
- Middle Aged
- Mutation
- Neoplasm Invasiveness
- Neoplasm Staging
- Odds Ratio