Article
Analysis of p53 mutation and cyclin D1 expression in breast tumors.
Pathology oncology research : POR - 1 Jan 1999
Tanyi J, Tory K, Bánkfalvi A, Shröder W, Rath W, Füzesi L
Abstract excerpt
P53 and cyclin D1 are interacting regulatory genes and both are frequently altered in breast cancer. We analysed p53 mutation by SSCP and sequencing methods as well as p53 protein accumulation immunohistochemically in 34 consecutively operated breast tumors. None of 4 fibroadenomas revealed p53 mutation or p53 protein accumulation. Mutation of p53 was present in 7 carcinomas. Immunohistochemistry revealed...
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