Article
TP53 mutation analyses on breast carcinomas: a study of paraffin-embedded archival material.
British journal of cancer - 1 Aug 1996
Gretarsdottir S, Tryggvadottir L, Jonasson J G, Sigurdsson H, Olafsdottir K, Agnarsson B A, Ogmundsdottir H, Eyfjörd J E
Abstract excerpt
The aim of this investigation was to examine the possibility of analysing TP53 mutations in archival paraffin-embedded material with the constant denaturant gel electrophoresis (CDGE) method. We extracted DNA from 193 archival primary breast carcinoma samples, diagnosed in 1981-83; further analys...
Topics
- Amino Acid Sequence
- Base Sequence
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Carcinoma, Lobular
- Conserved Sequence
- DNA Mutational Analysis
- DNA, Neoplasm
- Disease-Free Survival
- Exons
- Female
- Frameshift Mutation
- Genes, p53
- Histological Techniques
- Humans