The role of p53 mutations in bilateral breast carcinoma.

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Article

The role of p53 mutations in bilateral breast carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 1995

Ackerman J, Baunoch D A, Gimotty P, George J, Lane M A, Dawson P J

Abstract excerpt

Mutations of the tumor suppressor gene p53 have been implicated in certain familial cases of breast cancer. We examined a series of 38 cases of nonfamilial bilateral breast cancer using antibodies CM1 and DO7 to p53 wild-type and mutant protein (Novocastra Laboratories) by the avidin-biotin-perox...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Breast Neoplasms
Carcinoma, Ductal, Breast
DNA Primers
DNA, Neoplasm
Exons
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Immunoenzyme Techniques
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 7617647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7617647-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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