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Article

Sequence Polymorphisms in<i>pfcrt</i>Are Strongly Associated with Chloroquine Resistance in<i>Plasmodium falciparum</i>

15 May 2001

Abstract excerpt

To the Editor —A recent publication by Fidock et al. [1] reported a perfect correlation between the chloroquine-resistant (CQR) phenotype in Plasmodium falciparum and sequence polymorphisms in pfcrt [1]. A mutation, K76T, in pfcrt was shown to be present in all CQR isolates and absent from all chloroquine-susceptible (CQS) isolates tested. Besides K76T, all tested CQR parasites have multiple additional mutations,...

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PMID: 11319698
DOI: 10.1086/320206

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