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Article

Polymorphisms in the<i>Plasmodium falciparum pfcrt</i>and<i>pfmdr‐1</i>Genes and Clinical Response to Chloroquine in Kampala, Uganda

1 May 2001

Abstract excerpt

The molecular mechanism of chloroquine resistance in Plasmodium falciparum remains uncertain. Polymorphisms in the pfcrt and pfmdr-1 genes have been associated with chloroquine resistance in vitro, although field studies are limited. In evaluations of known polymorphisms in parasites from patients with uncomplicated malaria in Kampala, Uganda, the presence of 8 pfcrt mutations and 2 pfmdr-1 mutations did not...

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PMID: 11294677
DOI: 10.1086/319865

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Polymorphisms in the<i>Plasmodium falciparum pfcrt</i>and<i>pfmdr‐1</i>Genes and Clinical Response to Chloroquine in Kampala, UgandaPMID 11294677Read ↗

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