Article
[Plasmodium falciparum: point mutations of pcfrt and chloroquine susceptibility].
Annales pharmaceutiques francaises - 1 Sept 2001
Durand R, Le Bras J
Abstract excerpt
Recent transfection based studies demonstrated that cg2, a candidate gene for chloroquine resistance in Plasmodium faiciparum, was not the resistance determinant. A further analysis of the initial 36 kb locus comprising the cg2 gene led to the discovery of another gene, pfcrt, which was absolutely associated with chloroquine resistance in forty parasite lines. The aim of this study was to evaluate, in 146...
Topics
- Animals
- Antimalarials
- Chloroquine
- Drug Resistance
- Genes, Protozoan
- Genotype
- Membrane Proteins
- Membrane Transport Proteins
- Plasmodium falciparum
- Point Mutation
- Protozoan Proteins