Article
Role of pfmdr1 mutations on chloroquine resistance in Plasmodium falciparum isolates with pfcrt K76T from Papua New Guinea.
Acta tropica - 1 May 2006
Mita Toshihiro, Kaneko Akira, Hombhanje Francis, Hwaihwanje Ilomo, Takahashi Nobuyuki, Osawa Hikota, Tsukahara Takahiro, Masta Andrew, Lum Jeffery K, Kobayakawa Takatoshi, Ishizaki Takashi, Björkman Anders
Abstract excerpt
The N86Y mutation in pfmdr1 is reported to play an additional role for the chloroquine resistance in Plasmodium falciparum isolates. However, not much has been done to clarify whether this mutation augments the level of chloroquine resistance in the isolates harboring pfcrt K76T mutation. We compared the in vitro chloroquine efficacy between pfcrt K76T mutant parasites with or without N86Y mutation from Papua New...
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