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Article

pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines.

Antimicrobial agents and chemotherapy - 1 Nov 2003

Chen Nanhua, Kyle Dennis E, Pasay Cielo, Fowler Elizabeth V, Baker Joanne, Peters Jennifer M, Cheng Qin

Abstract excerpt

Mutations in the pfcrt and pfmdr1 genes have been associated with chloroquine resistance in Plasmodium falciparum. Ten and five mutations, respectively, have been identified in these genes from chloroquine-resistant parasites worldwide. Mutation patterns in pfcrt revealed that chloroquine resistance evolved independently in southeast Asia, South America, and Papua New Guinea. However, the evolution of chloroquine...

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Identifiers

PMID: 14576108
DOI: 10.1128/AAC.47.11.3500-3505.2003
PMCID: PMC253797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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