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Article

Molecular and Physiologic Basis of Quinoline Drug Resistance in<i>Plasmodium Falciparum</i>malaria

1 May 2009

Abstract excerpt

30 years before the discovery of the pfcrt gene, altered cellular drug accumulation in drug-resistant malarial parasites had been well documented. Heme released from catabolized hemoglobin was thought to be a key target for quinoline drugs, and additional modifications to quinoline drug structure in order to improve activity against chloroquine-resistant malaria were performed in a few laboratories. However,...

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PMID: 19416013
DOI: 10.2217/fmb.09.15

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