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<i>pfmdr1</i> mutations associated with chloroquine resistance incur a fitness cost in <i>Plasmodium falciparum</i>

1 Feb 2005

Abstract excerpt

Efforts to control malaria worldwide have been hindered by the development and expansion of parasite populations resistant to many first-line antimalarial compounds. Two of the best-characterized determinants of drug resistance in the human malaria parasite Plasmodium falciparum are pfmdr1 and pfcrt, although the mechanisms by which resistance is mediated by these genes is still not clear. In order to determine...

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PMID: 15686571
DOI: 10.1111/j.1365-2958.2004.04470.x

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