Article
Lack of association between putative transporter gene polymorphisms in Plasmodium falciparum and chloroquine resistance in imported malaria isolates from Africa.
Malaria journal - 28 Mar 2006
Cojean Sandrine, Noël Alain, Garnier Dimitri, Hubert Véronique, Le Bras Jacques, Durand Rémy
Abstract excerpt
BACKGROUND: Plasmodium falciparum drug resistance represents a major health problem in malaria endemic countries. The mechanisms of resistance are not fully elucidated. Recently, an association between putative transporter gene polymorphisms and in vitro response to chloroquine (CQ) and quinine has been reported in culture-adapted, cloned isolates from various geographical origins. However, this was not confirmed...
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