Article
Analysis of pfcrt point mutations and chloroquine susceptibility in isolates of Plasmodium falciparum.
Molecular and biochemical parasitology - 25 Apr 2001
Durand R, Jafari S, Vauzelle J, Delabre J F, Jesic Z, Le Bras J
Abstract excerpt
Recent transfection based studies demonstrated that cg2, a candidate gene for chloroquine resistance in Plasmodium falciparum, was not the resistance determinant. A further analysis of the initial 36 kb locus comprising the cg2 gene led to the discovery of another gene, pfcrt, which was absolutely associated with chloroquine resistance in forty parasite lines [Fidock DA, Nomura T, Talley AT, Su XZ, Cooper R,...
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