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Article

Conversion of a gene-specific repressor to a regional silencer.

Genes & development - 15 Apr 2001

Rusché L N, Rine J

Abstract excerpt

In Saccharomyces cerevisiae, gene silencing at the HMR and HML loci is normally dependent on Sir2p, Sir3p, and Sir4p, which are structural components of silenced chromatin. Sir2p is a NAD+-dependent histone deacetylase required for silencing. Silencing can be restored in cells lacking Sir proteins by a dominant mutation in SUM1, which normally acts as a mitotic repressor of meiotic genes. This study found that...

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Identifiers

PMID: 11316790
DOI: 10.1101/gad.873601
PMCID: PMC312676

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Source receipt: pubmed, retrieved 7 Sept 2026.

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