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Article

Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa.

Molecular and cellular biology - 1 Mar 2006

McConnell Kristopher H, Müller Philipp, Fox Catherine A

Abstract excerpt

The HMR-E silencer is a DNA element that directs the formation of silent chromatin at the HMRa locus in Saccharomyces cerevisiae. Sir1p is one of four Sir proteins required for silent chromatin formation at HMRa. Sir1p functions by binding the origin recognition complex (ORC), which binds to HMR-E, and recruiting the other Sir proteins (Sir2p to -4p). ORCs also bind to hundreds of nonsilencer positions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16479013
DOI: 10.1128/MCB.26.5.1955-1966.2006
PMCID: PMC1430255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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