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Article

New alleles of SIR2 define cell-cycle-specific silencing functions.

Genetics - 1 Aug 2006

Matecic Mirela, Martins-Taylor Kristen, Hickman Merrit, Tanny Jason, Moazed Danesh, Holmes Scott G

Abstract excerpt

The establishment of transcriptional silencing in yeast requires cell-cycle progression, but the nature of this requirement is unknown. Sir2 is a protein deacetylase that is required for gene silencing in yeast. We have used temperature-sensitive alleles of the SIR2 gene to assess Sir2's contribution to silencing as a function of the cell cycle. When examined in vivo, these conditional alleles fall into two...

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Share to Chromatin Assembly and Disassembly
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

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Identifiers

PMID: 16783021
DOI: 10.1534/genetics.106.055491
PMCID: PMC1569706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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