Article
Canonical germinal center B cells may not dominate the memory response to antigenic challenge.
International immunology - 1 May 2001
Lu Y F, Singh M, Cerny J
Abstract excerpt
Spleen and bone marrow (BM) are the major sites of antibody production and anamnestic response in systemically immunized mice. We examined the VDJ segment repertoire of antibody plaque-forming cells (APFC) in those two sites in the course of antibody responses to the hapten nitrophenyl (NP). Individual IgG APFC expressed any one of 10 V(H) segments of the V186.2/V3 (J558) gene family: 186.2, 102, 23, C1H4, 165.l,...
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