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Article

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice.

The Journal of experimental medicine - 1 Mar 1996

Yang X, Stedra J, Cerny J

Abstract excerpt

The immune system of aged individuals often produces antibodies that have lower affinity and are less protective than antibodies from young individuals. Recent studies in mice suggested that antibodies produced by old individuals may be encoded by distinct immunoglobulin (Ig) genes and that the somatic hypermutation process in these individuals is compromised. The present study employed Ighb scid mice...

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Identifiers

PMID: 8642299
DOI: 10.1084/jem.183.3.959
PMCID: PMC2192365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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