Article
Recruiting memory B cells with changed antigenic specificity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1993
Ellenberger J, Creadon G, Zhang X, Wysocki L J
Abstract excerpt
During T cell-dependent antibody responses, the V region genes of responding B lymphocytes are physiologically mutated at a high rate. An intense selection process expands subclones of B cells producing mutant antibodies that bind Ag optimally. This implies that most mutant B cells and their anti...
Topics
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Base Sequence
- Epitopes
- Genes, Immunoglobulin
- Hemocyanins
- Immunization
- Immunoglobulin Variable Region
- Immunologic Memory
- Mice
- Molecular Sequence Data
- Mutation