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Article

Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes.

Diabetes - 1 Mar 2004

Laudes Matthias, Barroso Inês, Luan Jian'an, Soos Maria A, Yeo Giles, Meirhaeghe Aline, Logie Lisa, Vidal-Puig Antonio, Schafer Alan J, Wareham Nick J, O'Rahilly Stephen

Abstract excerpt

The transcription factor sterol regulatory element binding protein (SREBP)-1c is intimately involved in the regulation of lipid and glucose metabolism. To investigate whether mutations in this gene might contribute to insulin resistance, we screened the exons encoding the aminoterminal transcriptional activation domain in a cohort of 85 unrelated human subjects with severe insulin resistance. Two missense...

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PMID: 14988272
DOI: 10.2337/diabetes.53.3.842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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