Article
Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.
PloS one - 5 Aug 2009
Stylianou Ioannis M, Svenson Karen L, VanOrman Sara K, Langle Yanina, Millar John S, Paigen Beverly, Rader Daniel J
Abstract excerpt
Cardiovascular disease (CVD) is the largest cause of premature death in human populations throughout the world. Circulating plasma lipid levels, specifically high levels of LDL or low levels of HDL, are predictive of susceptibility to CVD. The scavenger receptor class B member 1 (SCARB1) is the primary receptor for the selective uptake of HDL cholesterol by liver and steroidogenic tissues. Hepatic SCARB1...
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