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Article

Testing for colon neoplasia susceptibility variants at the human COX2 locus.

Journal of the National Cancer Institute - 18 Apr 2001

Wiesner G L, Platzer P, Buxbaum S, Lewis S, MacMillen M, Olechnowicz J, Willis J, Chakravarti A, Elston R C, Markowitz S D

Abstract excerpt

BACKGROUND: Siblings and other first-degree relatives of patients with "sporadic" (i.e., apparently nonfamilial) colorectal cancer or precursor adenomatous colon polyps have an increased risk of developing colon neoplasia. This observation suggests the presence of inherited genetic determinants for sporadic colon neoplasia. Mice homozygous for a null cyclooxygenase 2 (COX2) (also called PTGS2) allele have a...

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Source

Identifiers

PMID: 11309440
DOI: 10.1093/jnci/93.8.635

Genes

PTGS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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