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Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance.

Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2014

Guda Kishore, Fink Stephen P, Milne Ginger L, Molyneaux Neil, Ravi Lakshmeswari, Lewis Susan M, Dannenberg Andrew J, Montgomery Courtney G, Zhang Shulin, Willis Joseph, Wiesner Georgia L, Markowitz Sanford D

Abstract excerpt

HPGDand SLCO2A1 genes encode components of the prostaglandin catabolic pathway, with HPGD encoding the degradative enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), and SLCO2A1 encoding the prostaglandin transporter PGT that brings substrate to 15-PGDH. HPGD-null mice show increased prostaglandin E2 (PGE2), marked susceptibility to developing colon tumors, and resistance to colon tumor prevention by...

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Identifiers

PMID: 24838973
DOI: 10.1158/1940-6207.CAPR-14-0108
PMCID: PMC4125515

Genes

HPGD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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