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Article

Linkage disequilibrium and haplotype analysis of COX-2 and risk of colorectal adenoma development.

Clinical and translational science - 1 Feb 2012

Kwagyan John, Apprey Victor, Ashktorab Hassan

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the promoter and untranslated region of cyclooxygenase (COX)-2, an inducible enzyme responsible for the synthesis of prostaglandins, have been reported to modulate the risk for many human cancers. We performed comprehensive linkage disequilibrium (LD) and haplotype analyses of 13 single nucleotide polymorphisms of the COX-2 gene and examined its susceptibility to adenoma...

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Identifiers

PMID: 22376259
DOI: 10.1111/j.1752-8062.2011.00373.x
PMCID: PMC3618970

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