Article
The inducible prostaglandin biosynthetic enzyme, cyclooxygenase 2, is not mutated in patients with attenuated adenomatous polyposis coli.
Cancer research - 1 Nov 1998
Spirio L N, Dixon D A, Robertson J, Robertson M, Barrows J, Traer E, Burt R W, Leppert M F, White R, Prescott S M
Abstract excerpt
Germ-line mutations in the APC gene cause adenomatous polyposis coli (APC), a syndrome in which patients develop hundreds to thousands of precancerous adenomatous colorectal polyps. We described previously an attenuated form of APC (AAPC) resulting from very 5' mutations in APC in which affected...
Topics
- Adenomatous Polyposis Coli
- Adult
- Aged
- Animals
- Cyclooxygenase 1
- Humans
- Isoenzymes
- Membrane Proteins
- Mice
- Middle Aged
- Mutation
- Promoter Regions, Genetic
- Prostaglandin-Endoperoxide Synthases
- RNA, Messenger