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Article

COX Selectivity and Animal Models for Colon Cancer

1 Jun 2002

Abstract excerpt

Early experiments performed during 1980s and 1990s using carcinogen-induced rat intestinal tumor models demonstrated the inhibitory effects of non-steroidal anti-inflammatory drugs (NSAIDs) on intestinal tumorigenesis. Furthermore, epidemiological studies and clinical trials for familial adenomatous polyposis (FAP) patients supported the possibility that NSAIDs can be used as chemopreventive agents. The major...

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PMID: 11945149
DOI: 10.2174/1381612023394953

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