Article
Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2005
Brosens Lodewijk A A, Iacobuzio-Donahue Christine A, Keller Josbert J, Hustinx Steven R, Carvalho Ralph, Morsink Folkert H, Hylind Linda M, Offerhaus G Johan, Giardiello Francis M, Goggins Michael
Abstract excerpt
BACKGROUND: Colorectal cancers arising in patients with familial adenomatous polyposis (FAP) can be largely prevented by polyp surveillance and prophylactic colectomy. As a result, duodenal adenocarcinoma has become a leading cause of death in patients with FAP. Cyclooxygenase 2 (COX-2) inhibitio...
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