Article
Three secretory phospholipase A(2) genes that map to human chromosome 1P35-36 are not mutated in individuals with attenuated adenomatous polyposis coli.
Cancer research - 1 Mar 1996
Spirio L N, Kutchera W, Winstead M V, Pearson B, Kaplan C, Robertson M, Lawrence E, Burt R W, Tischfield J A, Leppert M F, Prescott S M, White R
Abstract excerpt
Mutation of Pla2g2a, a secretory phospholipase A(2) gene, dramatically increases the number of intestinal polyps that develop in the multiple intestinal neoplasia (Min) mouse, a murine model for adenomatous polyposis coli in humans. We tested the hypothesis that mutation of the human homologue(s)...
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