Article
Three secretory phospholipase A(2) genes that map to human chromosome 1P35-36 are not mutated in individuals with attenuated adenomatous polyposis coli.
Cancer research - 1 Mar 1996
Spirio L N, Kutchera W, Winstead M V, Pearson B, Kaplan C, Robertson M, Lawrence E, Burt R W, Tischfield J A, Leppert M F, Prescott S M, White R
Abstract excerpt
Mutation of Pla2g2a, a secretory phospholipase A(2) gene, dramatically increases the number of intestinal polyps that develop in the multiple intestinal neoplasia (Min) mouse, a murine model for adenomatous polyposis coli in humans. We tested the hypothesis that mutation of the human homologue(s) of this gene might be responsible for the more severe phenotype (hundreds of polyps) seen in a subset of individuals...
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