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Article

An association between the PTGS2 rs5275 polymorphism and colorectal cancer risk in families with inherited non-syndromic predisposition.

European journal of human genetics : EJHG - 1 Dec 2013

Ross Jason, Lockett Linda, Brookes Diana, Tabor Bruce, Duesing Konsta, Buckley Michael, Lockett Trevor, Molloy Peter, Macrae Finlay, Young Graeme, Blanco Ignacio, Capella Gabriel, Hannan Garry N

Abstract excerpt

Recently our group completed a genome-wide linkage study investigating Australian and Spanish families with inherited risk of colorectal cancer (CRC). A minor linkage peak from that study located on chromosome 1 correlates with the location of a known CRC risk-modifying gene, prostaglandin synthase (PTGS2). PTGS2 encodes the inducible prostaglandin synthase enzyme cyclooxygenase-2 (COX-2). Prostaglandins are...

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Source

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Identifiers

PMID: 23531863
DOI: 10.1038/ejhg.2013.53
PMCID: PMC3831072

Genes

PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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