Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of COX-2 in intestinal cancer.

Annals of the New York Academy of Sciences - 1 Jan 1999

Williams C, Shattuck-Brandt R L, DuBois R N

Abstract excerpt

Cyclooxygenase (COX), the key regulatory enzyme for prostaglandin synthesis is transcribed from two distinct genes. COX-1 is expressed constitutively in most tissues, and COX-2 is induced by a wide variety of stimuli and was initially identified as an immediate-early growth response gene. In addi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Aspirin
Share to Cyclooxygenase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2 Inhibitors

Share to Cyclooxygenase Inhibitors

Share to Intestinal Neoplasms

Share to Isoenzymes

Share to Prostaglandin-Endoperoxide Synthases

Source

Identifiers

PMID: 10668484
DOI: 10.1111/j.1749-6632.1999.tb08725.x

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10668484-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of COX-2 in intestinal cancer.PMID 10668484Read ↗

Targeting cyclooxygenase‐2 for prevention and therapy of colorectal cancerSemantic proximity Read ↗

Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications.Semantic proximity Read ↗

Cyclooxygenase-2: a novel target for cancer chemotherapy?Semantic proximity Read ↗

[Cyclooxygenase 2 and carcinogenesis].Semantic proximity Read ↗

COX Selectivity and Animal Models for Colon CancerSemantic proximity Read ↗

Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal CancerSemantic proximity Read ↗

Differential expression of cyclooxygenase 2 in human colorectal cancerSemantic proximity Read ↗

Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesisSemantic proximity Read ↗

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potentialSemantic proximity Read ↗

Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2.Semantic proximity Read ↗

Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies.Semantic proximity Read ↗

The -765C allele of the cyclooxygenase-2 gene as a potential risk factor of colorectal cancer: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.