Article
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.
Human molecular genetics - 15 Apr 2001
Tanaka Y, Engelender S, Igarashi S, Rao R K, Wanner T, Tanzi R E, Sawa A, L Dawson V, Dawson T M, Ross C A
Abstract excerpt
Parkinson's disease (PD) is a common progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra. Although mutations in alpha-synuclein have been identified in autosomal dominant PD, the mechanism by which dopaminergic neural cell death occurs remains unknown. Proteins encoded by two other genes in which mutations cause familial PD, parkin and UCH-L1, are involved in...
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