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Article

Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2003

Dong Zhizhong, Ferger Boris, Paterna Jean-Charles, Vogel Denise, Furler Sven, Osinde Maribel, Feldon Joram, Büeler Hansruedi

Abstract excerpt

Mutations in the parkin gene are linked to autosomal-recessive juvenile parkinsonism (AR-JP). Parkin functions as a ubiquitin protein ligase in the degradation of several proteins, including the neuron-specific septin CDCrel-1. AR-JP-associated parkin mutations inhibit ubiquitination and degradat...

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PMID: 14530399
DOI: 10.1073/pnas.2132992100
PMCID: PMC218776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14530399-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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