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Article

Parkin suppresses wild-type alpha-synuclein-induced toxicity in SHSY-5Y cells.

Biochemical and biophysical research communications - 26 Sept 2003

Oluwatosin-Chigbu Yemisi, Robbins Alan, Scott Clay W, Arriza Jeffrey L, Reid John D, Zysk John R

Abstract excerpt

Current hypotheses concerning the mechanism of neuronal cell death in Parkinson's disease (PD) and related synucleopathies propose a functional interaction between parkin and alpha-synuclein (alphaS). Recently parkin was shown to suppress mutant alphaS-induced toxicity in primary neurons, providing a basis for an association between these proteins and neuronal loss [Neuron 36 (2000) 1007-1019]. We have asked if a...

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Identifiers

PMID: 12963044
DOI: 10.1016/j.bbrc.2003.08.059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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