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Article

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.

Human molecular genetics - 15 Dec 2005

Smith Wanli W, Jiang Haibing, Pei Zhong, Tanaka Yuji, Morita Hokuto, Sawa Akira, Dawson Valina L, Dawson Ted M, Ross Christopher A

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. Alpha-synuclein is a major component of Lewy bodies in sporadic PD, and mutations in alpha-synuclein cause autosomal-dominant hereditary PD. Here, we generated A53T mutant alpha-synuclein-inducible PC12 cell lines using the Tet-off regulatory system. Inducing...

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PMID: 16239241
DOI: 10.1093/hmg/ddi396

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