Article
Induction of neuronal death by alpha-synuclein.
The European journal of neuroscience - 1 Aug 2000
Saha A R, Ninkina N N, Hanger D P, Anderton B H, Davies A M, Buchman V L
Abstract excerpt
The molecular and cellular mechanisms underlying neuronal loss in neurodegenerative diseases are unclear. It is generally thought that aggregation of mutated, abnormally modified or abnormally folded proteins leads to the accumulation of extracellular, intracellular or intranuclear deposits that severely compromise cell physiology, leading to the death of the affected neurons. However, there is growing evidence...
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