Article
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.
Neuron - 19 Dec 2002
Petrucelli Leonard, O'Farrell Casey, Lockhart Paul J, Baptista Melisa, Kehoe Kathryn, Vink Liselot, Choi Peter, Wolozin Benjamin, Farrer Matthew, Hardy John, Cookson Mark R
Abstract excerpt
One hypothesis for the etiology of Parkinson's disease (PD) is that subsets of neurons are vulnerable to a failure in proteasome-mediated protein turnover. Here we show that overexpression of mutant alpha-synuclein increases sensitivity to proteasome inhibitors by decreasing proteasome function. Overexpression of parkin decreases sensitivity to proteasome inhibitors in a manner dependent on parkin's...
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