Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

Brain research - 2 Jun 2000

Zhou W, Hurlbert M S, Schaack J, Prasad K N, Freed C R

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the appearance of intracytoplasmic inclusions called Lewy bodies (LB) in dopamine neurons in the substantia nigra and the progressive loss of these neurons. Recently, mutations in the alpha-synuclein gene have been identified in early-onset familial PD, and alpha-synuclein has been shown to be a major component of LB in all patients. Yet,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to alpha-Synuclein
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Mesencephalon

Share to Neurotoxins

Share to Oxidopamine

Share to Synucleins

Source

Identifiers

PMID: 10825478
DOI: 10.1016/s0006-8993(00)02215-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.PMID 10825478Read ↗

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.Semantic proximity Read ↗

Overexpression of human α-synuclein causes dopamine neuron death in primary human mesencephalic cultureSemantic proximity Read ↗

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity.Semantic proximity Read ↗

How can <scp>rAAV</scp>‐α‐synuclein and the fibril α‐synuclein models advance our understanding of Parkinson's disease?Semantic proximity Read ↗

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.Semantic proximity Read ↗

Selective loss of dopaminergic neurons and formation of Lewy body‐like aggregations in α‐synuclein transgenic fly neuronal culturesSemantic proximity Read ↗

Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.Semantic proximity Read ↗

Viral Vector Mediated Overexpression of Human α-Synuclein in the Nigrostriatal Dopaminergic Neurons: A New Model for Parkinson's DiseaseSemantic proximity Read ↗

α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cellsSemantic proximity Read ↗

Induction of neuronal death by alpha-synuclein.Semantic proximity Read ↗

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.Semantic proximity Read ↗

Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.