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Article

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).

The Journal of biological chemistry - 6 Feb 2004

Weskamp Gisela, Schlöndorff Johannes, Lum Lawrence, Becherer J David, Kim Tae-Wan, Saftig Paul, Hartmann Dieter, Murphy Gillian, Blobel Carl P

Abstract excerpt

Protein ectodomain shedding, the proteolytic release of the extracellullar domain of membrane-tethered proteins, can dramatically affect the function of cell surface receptors, growth factors, cytokines, and other proteins. In this study, we evaluated the activities involved in ectodomain shedding of p75NTR, a neurotrophin receptor with critical roles in neuronal differentiation and survival. p75NTR is shed in a...

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Identifiers

PMID: 14638693
DOI: 10.1074/jbc.M307974200

Genes

ADAM17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).PMID 14638693Read ↗

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The transmembrane domain of TACE regulates protein ectodomain shedding.Semantic proximity Read ↗

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