Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurotrophins: the biological paradox of survival factors eliciting apoptosis.

Cell death and differentiation - 1 May 1998

Casaccia-Bonnefil P, Kong H, Chao M V

Abstract excerpt

Neurotrophins are target-derived soluble polypeptides required for neuronal survival. Binding of neurotrophins to Trk receptor tyrosine kinases initiate signaling cascades that promote cell survival and differentiation. All family members bind to another receptor (p75NTR), which belongs to the tu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Dosage
Share to Ligands
Share to Nerve Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurons

Share to Protein Structure, Secondary

Share to Receptor, Nerve Growth Factor

Share to Receptor Protein-Tyrosine Kinases

Share to Receptors, Nerve Growth Factor

Source

Identifiers

PMID: 10200484
DOI: 10.1038/sj.cdd.4400377

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10200484-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurotrophins: the biological paradox of survival factors eliciting apoptosis.PMID 10200484Read ↗

The dual nature of neurotrophins.Semantic proximity Read ↗

Neurotrophins and Their Receptors—Current Concepts and Implications for Neurologic DiseaseSemantic proximity Read ↗

Selectivity in neurotrophin signaling: theme and variations.Semantic proximity Read ↗

Characterization of a p75(NTR) apoptotic signaling pathway using a novel cellular model.Semantic proximity Read ↗

Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor.Semantic proximity Read ↗

Neuronal apoptosis induced by morphine withdrawal is mediated by the p75 neurotrophin receptor.Semantic proximity Read ↗

TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism.Semantic proximity Read ↗

Neurotrophins and neurodegenerationSemantic proximity Read ↗

Apoptosis in the nervous system.Semantic proximity Read ↗

Neurotrophins. Keeping track of changing neurotrophic theory.Semantic proximity Read ↗

Induction of Postnatal Schwann Cell Death by the Low-Affinity Neurotrophin ReceptorIn Vitroand after AxotomySemantic proximity Read ↗

Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.