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Article

Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 May 2016

Tanaka Kazuhiro, Kelly Claire E, Goh Ket Yin, Lim Kim Buay, Ibáñez Carlos F

Abstract excerpt

UNLABELLED: The p75 neurotrophin receptor (p75(NTR)) mediates neuronal death in response to neural insults by activating a caspase apoptotic pathway. The oligomeric state and activation mechanism that enable p75(NTR) to mediate these effects have recently been called into question. Here, we have investigated mutant mice lacking the p75(NTR) death domain (DD) or a highly conserved transmembrane (TM) cysteine...

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Identifiers

PMID: 27194337
DOI: 10.1523/JNEUROSCI.4536-15.2016
PMCID: PMC6601771

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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